Table 1.
Comparison of the methods used to generate humanized mice.
| Method | Advantage | Disadvantage | |||||
|---|---|---|---|---|---|---|---|
| HIS reconstitution | Material availability | Autologous tumor to IS | Long-term studies | GvHD | Time consuming | Technical difficulties | |
| PBMC | +/− | + | + | – | + | – | – |
| HSC | + | +/− | − | + | − | + | +/− |
| BLT | ++ | – | – | + | +/− | + | + |
| SPMC | +/− | +/− | − | − | + | − | +/− |
HIS, Human immune system; GvHD, Graft versus host disease; PBMC, Peripheral blood mononuclear cell; HSC, Hematopoietic stem cell; BLT, Bone liver thymus; SPMC, Spleen mononuclear cell; ++, Advantage or disadvantage highly present in the model; + present in the model; +/–, somewhat present in the model; –, absent from the model.