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. 2021 Nov 7;81(17):2035–2046. doi: 10.1007/s40265-021-01615-w
First-in-class rFVIII-Fc fusion protein.
Half-life ≈ 1.4−1.8 times that of conventional rFVIII products.
Efficacy and safety demonstrated in phase III clinical trials; effectiveness demonstrated in real-world studies.
Expected rate of inhibitor development in PUPs.