Table 3.
Univariate and Multivariate Logistic Regression Analysis of Risk Factor of Bone Metastasis in Training Cohort
| Variables | Univariate Logistic Regression | Multivariate Logistic Regression | ||||
|---|---|---|---|---|---|---|
| OR | 95% CI | P | OR | 95% CI | P | |
| Age (years) | ||||||
| <64 | Reference | |||||
| 64–76 | 0.865 | 0.597–1.252 | 0.442 | |||
| >76 | 0.701 | 0.385–1.278 | 0.246 | |||
| Tumour site | ||||||
| Npple/central | Reference | |||||
| Upper-inner | 0.504 | 0.245–1.034 | 0.062 | |||
| Lower-inner | 0.545 | 0.216–1.375 | 0.199 | |||
| Upper-outer | 0.415 | 0.217–0.795 | 0.008 | |||
| Lower-outer | 0.627 | 0.279–1.409 | 0.259 | |||
| Others | 0.975 | 0.538–1.767 | 0.934 | |||
| Laterality | ||||||
| Left | Reference | |||||
| Right | 1.094 | 0.797–1.501 | 0.578 | |||
| Histology | ||||||
| Duct | Reference | |||||
| Lobular | 2.147 | 1.33–3.465 | 0.002 | 1.976 | 1.074–3.480 | 0.0226 |
| Duct+lobular | 0.834 | 0.306–2.27 | 0.722 | 0.805 | 0.214–2.268 | 0.7145 |
| Others | 1.66 | 0.89–3.095 | 0.111 | 1.7 | 0.753–3.545 | 0.1774 |
| Grade | ||||||
| Grade1 | Reference | |||||
| Grade2 | 2.403 | 1.419–4.071 | 0.001 | |||
| Grade3 | 2.904 | 1.691–4.986 | <0.001 | |||
| Grade4 | 17.734 | 3.828–82.146 | <0.001 | |||
| Summary stage | ||||||
| Local | Reference | |||||
| Regional | 1 | 0-Inf | 1 | |||
| Distant | 2.0284E+10 | 0-Inf | 0.978 | |||
| T_stage | ||||||
| T1 | Reference | |||||
| T2 | 3.515 | 2.266–5.454 | <0.001 | 1.349 | 0.820–2.241 | 0.242 |
| T3 | 9.44 | 5.57–15.999 | <0.001 | 1.641 | 0.874–3.042 | 0.118 |
| T4 | 34.849 | 21.578–56.283 | <0.001 | 2.514 | 1.326–4.757 | 0.005 |
| N_stage | ||||||
| N0 | Reference | |||||
| N1 | 7.678 | 5.103–11.552 | <0.001 | 4.193 | 2.646–6.747 | <0.001 |
| N2 | 11.726 | 6.805–20.208 | <0.001 | 9.777 | 5.096–18.519 | <0.001 |
| N3 | 22.84 | 13.525–38.571 | <0.001 | 9.348 | 4.675–18.516 | <0.001 |
| Surg prim site | ||||||
| No | Reference | |||||
| Yes | 0.014 | 0.01–0.02 | <0.001 | 0.022 | 0.015–0.035 | <0.001 |
| Tumour size (cm) | ||||||
| <2 | Reference | |||||
| 2~5 | 3.667 | 2.416–5.567 | <0.001 | |||
| >5 | 12.18 | 7.785–19.056 | <0.001 | |||
| Brain_metastasis | ||||||
| No | Reference | |||||
| Yes | 0 | 0-Inf | 0.979 | |||
| Liver_metastasis | ||||||
| No | Reference | |||||
| Yes | 0 | 0–6.782e+304 | 0.975 | |||
| Lung_metastasis | ||||||
| No | Reference | |||||
| Yes | 0 | 0-Inf | 0.976 | |||
| Subtype | ||||||
| HR-/HER2- | Reference | |||||
| HR-/HER2+ | 1.468 | 0.563–3.826 | 0.432 | |||
| HR+/HER2- | 1.406 | 0.711–2.781 | 0.327 | |||
| HR+/HER2+ | 2.112 | 0.981–4.544 | 0.056 | |||
| ER | ||||||
| Negative | Reference | |||||
| Positive | 1.884 | 1.061–3.328 | 0.03 | 2.617 | 1.487–4.886 | 0.002 |
| PR | ||||||
| Negative | Reference | |||||
| Positive | 1.074 | 0.738–1.562 | 0.709 | |||
| HER2 | ||||||
| Negative | Reference | |||||
| Positive | 1.398 | 0.949–2.059 | 0.09 | |||
Abbreviations: HER2, human epidermal growth factor receptor 2; ER, estrogen receptor; PR, progesterone receptor.