Table 4.
Univariate and Multivariate Cox Regression Analysis of Breast Cancer in Training Cohort
| Variables | Univariate Cox Regression | Multivariate Cox Regression | ||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Age (years) | ||||
| <64 | Reference | |||
| 64–76 | 1.708 (1.465–1.991) | <0.001 | 2.065 (1.767–2.414) | <0.001 |
| >76 | 5.103 (4.392–5.929) | <0.001 | 5.756 (4.914–6.742) | <0.001 |
| Tumour site | ||||
| Npple/central | Reference | |||
| Upper-inner | 0.604 (0.457–0.799) | <0.001 | ||
| Lower-inner | 0.75 (0.534–1.054) | 0.097 | ||
| Upper-outer | 0.586 (0.456–0.752) | <0.001 | ||
| Lower-outer | 0.643 (0.465–0.888) | 0.007 | ||
| Others | 0.815 (0.641–1.038) | 0.098 | ||
| Laterality | ||||
| Left | Reference | |||
| Right | 0.971 (0.856–1.101) | 0.644 | ||
| Histology | ||||
| Duct | Reference | |||
| Lobular | 1.091 (0.849–1.403) | 0.495 | ||
| Duct+lobular | 1.019 (0.719–1.443) | 0.916 | ||
| Others | 1.376 (1.06–1.784) | 0.016 | ||
| Grade | ||||
| Grade1 | Reference | |||
| Grade2 | 1.428 (1.177–1.733) | <0.001 | 1.142 (0.936–1.394) | 0.189 |
| Grade3 | 2.575 (2.13–3.114) | <0.001 | 1.626 (1.306–2.024) | <0.001 |
| Grade4 | 5.09 (2.381–10.879) | <0.001 | 3.3 (1.533–7.105) | 0.002 |
| Summary stage | ||||
| Local | Reference | |||
| Regional | 2.52 (2.201–2.886) | <0.001 | 1.916 (1.399–2.624) | <0.001 |
| Distant | 15.318 (12.618–18.596) | <0.001 | 4.784 (3.274–6.988) | <0.001 |
| T_stage | ||||
| T1 | Reference | |||
| T2 | 2.324 (2.009–2.688) | <0.001 | 1.58 (1.344–1.857) | <0.001 |
| T3 | 4.848 (3.966–5.925) | <0.001 | 2.555 (2.036–3.206) | <0.001 |
| T4 | 9.676 (7.797–12.007) | <0.001 | 1.822 (1.374–2.417) | <0.001 |
| N_stage | ||||
| N0 | Reference | |||
| N1 | 2.054 (1.774–2.379) | <0.001 | 0.899 (0.662–1.222) | 0.499 |
| N2 | 4.004 (3.242–4.945) | <0.001 | 1.739 (1.235–2.450) | 0.002 |
| N3 | 7.15 (5.788–8.833) | <0.001 | 1.695 (1.212–2.370) | 0.002 |
| Surg prim site | ||||
| No | Reference | |||
| Yes | 0.109 (0.092–0.129) | <0.001 | 0.304 (0.244–0.377) | <0.001 |
| Tumour size (cm) | ||||
| <2 | Reference | |||
| 2~5 | 2.33 (2.016–2.692) | <0.001 | ||
| >5 | 5.685 (4.779–6.764) | <0.001 | ||
| Bone_metastasis | ||||
| No | Reference | |||
| Yes | 9.578 (7.503–12.228) | <0.001 | ||
| Brain_metastasis | ||||
| No | Reference | |||
| Yes | 19.134 (6.15–59.531) | <0.001 | ||
| Liver_metastasis | ||||
| No | Reference | |||
| Yes | 13.659 (7.535–24.76) | <0.001 | ||
| Lung_metastasis | ||||
| No | Reference | |||
| Yes | 9.049 (5.6–14.624) | <0.001 | ||
| Subtype | ||||
| HR-/HER2- | Reference | |||
| HR-/HER2+ | 0.497 (0.372–0.665) | <0.001 | 0.443 (0.329–0.597) | <0.001 |
| HR+/HER2- | 0.368 (0.312–0.434) | <0.001 | 0.941 (0.549–1.612) | 0.832 |
| HR+/HER2+ | 0.402 (0.316–0.512) | <0.001 | 0.761 (0.441–1.309) | 0.327 |
| ER | ||||
| Negative | Reference | |||
| Positive | 0.455 (0.395–0.525) | <0.001 | 0.51 (0.303–0.859) | 0.011 |
| PR | ||||
| Negative | Reference | |||
| Positive | 0.526 (0.462–0.599) | <0.001 | ||
| HER2 | ||||
| Negative | Reference | |||
| Positive | 1.007 (0.851–1.193) | 0.933 | ||
Abbreviations: HER2, human epidermal growth factor receptor 2; ER, estrogen receptor; PR, progesterone receptor.