Table 5.
Univariate and Multivariate Cox Regression Analysis of BCBM in Training Cohort
| Variables | Univariate Cox Regression | Multivariate Cox Regression | ||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Age (years) | ||||
| <64 | Reference | |||
| 64–76 | 1.691 (1.033–2.768) | 0.037 | ||
| >76 | 1.783 (0.799–3.979) | 0.158 | ||
| Tumour site | ||||
| Npple/central | Reference | |||
| Upper-inner | 0.526 (0.208–1.334) | 0.176 | ||
| Lower-inner | 3.142 (0.839–11.774) | 0.089 | ||
| Upper-outer | 0.799 (0.366–1.746) | 0.574 | ||
| Lower-outer | 0.859 (0.269–2.746) | 0.798 | ||
| Others | 0.781 (0.383–1.59) | 0.495 | ||
| Laterality | ||||
| Left | Reference | |||
| Right | 1.631 (1.029–2.585) | 0.037 | ||
| Histology | ||||
| Duct | Reference | |||
| Lobular | 1.974 (1.077–3.617) | 0.028 | 2.547 (1.444–4.491) | 0.001 |
| Duct+lobular | 0.788 (0.192–3.234) | 0.741 | 0.533 (0.162–1.751) | 0.3 |
| Others | 0.256 (0.062–1.05) | 0.058 | 0.472 (0.210–1.064) | 0.07 |
| Grade | ||||
| Grade1 | Reference | |||
| Grade2 | 1.38 (0.489–3.893) | 0.543 | 1.718 (0.731–4.037) | 0.214 |
| Grade3 | 1.78 (0.629–5.033) | 0.277 | 2.764 (1.1530–6.629) | 0.022 |
| Grade4 | 4.674 (1.041–20.997) | 0.044 | 4.593 (1.127–18.722) | 0.033 |
| Summary stage | ||||
| Local | Reference | |||
| Regional | 18.042 (2.281–142.721) | 0.006 | ||
| Distant | NA (NA-NA) | NA | ||
| T_stage | ||||
| T1 | Reference | |||
| T2 | 0.954 (0.469–1.94) | 0.896 | ||
| T3 | 1.161 (0.526–2.56) | 0.712 | ||
| T4 | 1.61 (0.788–3.29) | 0.192 | ||
| N_stage | ||||
| N0 | Reference | |||
| N1 | 0.679 (0.366–1.261) | 0.22 | ||
| N2 | 0.562 (0.235–1.342) | 0.195 | ||
| N3 | 1.418 (0.684–2.942) | 0.348 | ||
| Surg prim site | ||||
| No | Reference | |||
| Yes | 0.518 (0.307–0.875) | 0.014 | 0.421 (0.262–0.677) | <0.001 |
| Tumour size (cm) | ||||
| <2 | Reference | |||
| 2~5 | 1.018 (0.502–2.063) | 0.96 | ||
| >5 | 1.238 (0.605–2.534) | 0.559 | ||
| Subtype | ||||
| HR-/HER2- | Reference | |||
| HR-/HER2+ | 0.043 (0.005–0.356) | 0.004 | 0.074 (0.015–0.365) | 0.001 |
| HR+/HER2- | 0.165 (0.072–0.378) | 0 | 0.36 (0.149–0.868) | 0.023 |
| HR+/HER2+ | 0.12 (0.043–0.338) | 0 | 0.168 (0.062–0.456) | <0.001 |
| ER | ||||
| Negative | Reference | |||
| Positive | 0.599 (0.287–1.25) | 0.172 | ||
| PR | ||||
| Negative | Reference | |||
| Positive | 0.635 (0.385–1.047) | 0.075 | 0.512 (0.294–0.892) | 0.018 |
| HER2 | ||||
| Negative | Reference | |||
| Positive | 0.57 (0.292–1.113) | 0.1 | ||
Abbreviations: HER2, human epidermal growth factor receptor 2; ER, estrogen receptor; PR, progesterone receptor.