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. 2021 Dec 1;12:7004. doi: 10.1038/s41467-021-27309-1

Fig. 7. GP73 expression is pathologically elevated in NAFLD patients without obesity.

Fig. 7

a GP73 mRNA expression in multiple tissues from mice fed a regular diet (Reg) or a high-cholesterol, high-cholate diet (HFHCC) for 1 month (n = 6 per group). Differences between the two groups were evaluated using two-sided unpaired Student’s t-test. Data are presented as mean ± SEM. ***P < 0.001. b GP73 protein levels in the livers from mice fed HFHCC for 7 days (n = 2 per group). α-Tubulin was used as the equal loading control. Relative expression was calculated as the fold change in expression relative to the expression in No. 1 control mice. c–f Plasma adiponectin (c), leptin (d), and adiponectin-to-leptin ratio (A/L ratio; e); GP73 levels (f) in NAFLD patients without obesity and non-obese healthy subjects (n = 14 per group). Differences between the two groups were evaluated using the two-sided unpaired Student’s t-test. Data are presented as mean ± SEM. ns, no statistical significance; *P < 0.05; ***P < 0.001.