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. 2021 Dec 1;12:7004. doi: 10.1038/s41467-021-27309-1

Fig. 8. GP73 blockade improves whole-body metabolism in non-obese NAFLD mouse model.

Fig. 8

a GP73 mRNA expression in livers from mice fed a regular or HFHCC diet for 1 month and injected with siGP73 or control RNAi oligos twice a week (n = 6 per group). Differences between the two groups were evaluated using unpaired Student’s t-test. Data are presented as mean ± SEM. ***P < 0.001. b–j Liver-to-body weight ratio (b); hepatic levels of CHO (c) and TGs (d); plasma levels of AST (e) and ALT (f); fasting glucose levels (g) and GTT (h); body weight (i) and inguinal WAT-to-body weight ratio (j) in the four groups above (n = 6 per group). Differences between two groups were evaluated using unpaired Student’s t-test. Data are presented as mean ± SEM. ns, no statistical significance; *P < 0.05; **P < 0.01; ***P < 0.001.