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. 2021 Dec 1;11:23202. doi: 10.1038/s41598-021-02495-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Univariate Cox proportional hazard models for age at diagnosis, fractal dimension, lacunarity and tumor radius, across all three regions (necrosis n = 390, enhancement with necrosis n = 402, edema n = 257). Both fractal dimension and lacunarity of edema-related abnormalities are significant prognostic indicators of overall survival. Age at diagnosis was significant for all three regions, while radius was significant for both necrosis and enhancement with necrosis. Values of these tests can be found in Supplement 4.