Fig.12.

a TEM images of MSNs (i), hydrophobically modified MSNs (ii), and β-CD stabilized hydrophobic MSNs (iii). Schematic showing the molecular structure of hydrophobically modified MSN pore walls and β-CD (iv). Fluorescence assay showing in vitro ROS generation by MSNs after ultrasound exposure (v). b In vivo sonodynamic therapy using β-CD stabilized hydrophobic MSNs in ZR75-30 tumor model in mice. Relative tumor volumes of mice untreated or treated with ultrasound in the presence of nanoparticles at different concentrations (i). Photographs (ii) and H&E staining (iii) of tumors at end of the experiment.

Adapted from reference [48], Copyright 2014, John Wiley and Sons