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. 2021 Dec 1;8:39. doi: 10.1186/s40580-021-00287-2

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Representative images showing the cavitation events as bright spots generated by MSN based GSNs under HIFU insonation of nanoparticles with or without BSA coating in ethanol (90%) or water (top). Calculated relative intensities from the acquired movies of nanoparticles during HIFU insonation (bottom). b Nanoparticle tracking analysis of the nanoparticles in water. Insets show the TEM images. Scale bars are 50 nm. Nanoparticles; MCM-48MD: hydrophobically modified MSNs using methyltrimethoxysilane, MCM-48R: MSNs with rough nanoparticle surfaces.

Adapted from reference [78], Copyright 2016, American Chemical Society