Fig. 1.

Differences between phenotype definitions and continents across the 34 data-sets used for discovery-stage genetic analyses.

(a) The various data-sets used four different definitions for age at onset: diagnostic interview, impairment/help-seeking, pharmacotherapy and mixed. (b) The untransformed age at onset differed significantly between cohorts, depending on the phenotype definition used and the continent of origin.

Au, Australia; Diagnostic, diagnostic interview; D, diagnostic interview; I, impairment/help-seeking; M, mixed; P, pharmacotherapy. n.s., not significant; P > 0.05; *** P < 0.001.