Table 2.

The association of age and polarity at onset with disease characteristics in two European bipolar disorder cohorts

Disease characteristic	AAO					PAO
	n	Odds ratio	95% CI	Unadjusted P	Adjusted Pa	n	Odds ratio	95% CI	Unadjusted P	Adjusted P
Delusions	1612	0.71	0.64–0.79	1.61 × 10−9	1.45 × 10−8*	1298	0.62	0.49–0.79	1.04 × 10−4	6.24 × 10−4*
Hallucinations	1594	0.83	0.74–0.92	3.5 × 10−4	1.40 × 10−3*	1290	0.93	0.74–1.17	5.22 × 10−1	1.00 × 100
Current smoking	1594	0.98	0.89–1.09	7.50 × 10−1	7.50 × 10−1	1282	1.12	0.89–1.41	3.39 × 10−1	1.00 × 100
Suicidal ideation	1518	0.79	0.71–0.88	2.31 × 10−5	1.62 × 10−4*	1280	1.68	1.32–2.13	2.11 × 10−5	1.48 × 10−4*
Suicide attempt	1537	0.78	0.69–0.88	2.73 × 10−5	1.64 × 10−4*	1262	1.58	1.24–2.02	2.67 × 10−4	1.34 × 10−3*
Educational attainment	1636	1.17	1.06–1.29	2.77 × 10−3	8.31 × 10−3*	1319	1.06	0.85–1.33	5.93 × 10−1	1.00 × 100
Living together	1357	1.28	1.15–1.44	1.01 × 10−5	8.08 × 10−5*	–	–	–	–	–

AAO, age at onset; PAO, polarity at onset; n, total number of participants from the Dutch and German cohorts.

* P < 0.05

^a.After Bonferroni–Holm correction.