Fig. 4. Community networks underlying Pol II–Rad26 functional dynamics during the ATPase cycle.

a Consensus communities are identified from dynamic network analysis and mapped to the structure of Pol II–Rad26 complex. Communities are color-coded and labeled. Net change in contact probabilities across Pol II–Rad26 communities during the ATP hydrolysis cycle: (b), apo to ATP transition; (c) ATP to ADP transition; (d) ADP to apo transition. The radius of community vertex is correlated to the number of residues included in the community. The gray and black edges between communities (betweenness) indicate gain(+)/loss(−) of dynamic contacts.