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. 2021 Dec 1;12(12):1123. doi: 10.1038/s41419-021-04403-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Immunohistochemical staining of p-SYK and α-SMA in liver tissues of fibrosis patients with different ishak grades (Ishak0, Ishak3–4) (magnification 40X). B Confocal immunofluorescence staining of p-SYK and α-SMA in liver tissues of fibrosis patients with different ishak grades (Ishak0, Ishak3–4) (magnification 40X), DAPI as nuclear localization. C Serum ALT and AST levels in mice injected with CCL4 for 4 and 8 weeks, oil as a control. D Assessed the expression of SYK, α-SMA, and col1A1 in the liver of mice treated with CCL4 for 4 and 8 weeks were by qPCR, and oil was used as a control. E The expression of SYK and α-SMA in the liver of mice 2 and 4 weeks after BDL surgery were determined by qPCR, and sham was used as a control. F Correlation analysis between the expression of SYK and α-SMA in CCL4 and BDL models. G Western Blot was used to analyze the protein level of p-SYK, TGF-β and α-SMA in the liver of mice injected with CCL4 for 4 or 8 weeks and mice 2 or 4 weeks after BDL, oil and sham were used as controls, respectively. H HE, Sirius red, masson staining and immunohistochemistry of α-SMA and p-SYK were performed on the livers of mice given CCL4 for 8 weeks and mice 4 weeks after BDL, respectively. Oil and sham were used as controls. I Confocal immunofluorescence staining of p-SYK and α-SMA were performed on the livers of a mouse injected with CCL4 for 8 weeks and mice 4 weeks after BDL, respectively, with DAPI as the nuclear localization.