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. 2021 Dec 1;11:23233. doi: 10.1038/s41598-021-02373-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Enrichment of CTCF or YY1 binding sites in promoter interacting regions interacting with RNAs (RNA-PIRs). (A) Numbers and percentages of PIRs in human embryonic stem cells (hESCs) interacting with RNAs and containing binding sites of CTCF or YY1. (B) Odds Ratios (ORs) and p-values of CTCF or YY1 site enrichment were estimated from binary logistic regression analyses including PIR size as a covariate. ***p-values obtained from binary logistic regression analyses were lower than the p-values obtained from the same analyses performed with 1000 randomised CTCF or YY1 site sets (permutation P < 1.0x10^-3).