Fig. 6.

Schematic representation of dynamic cell–matrix crosstalk during immune cell–matrix interactions. Material–cell crosstalk is represented through degradation of matrix by enzymes produced by cells, the production of ECM proteins by cells, and the immunomodulatory domains in the ECM described in this review. Cellular crosstalk is depicted via the production of, and interaction with, cytokines and chemokines by the various cell types. Reproduced from Rowley et al., [103] Adv. Healthcare Mater. 8 1801578, with permission.