Fig. 7.

SIS/LXW7-DS-SILY constructs accelerate wound closure and support survival of ZDF-EPCs under ischemic condition.

A. Representative images of healing in wounds treated with different groups at days 0, 3, 7, 11 and 14. B. Quantification of the wound closure rates of different groups. a) SIS/LXW7-DS-SILY group was significantly better compared to SIS group. There was a trend that the SIS/DS-SILY group was better than the SIS group but the difference was not statistically significant. b) SIS/LXW7-DS-SILY/EPCs group was significantly better than the SIS/DS-SILY/EPCs and SIS/EPCs groups. c) SIS/LXW7-DS-SILY/EPCs group was significantly better compared to SIS/LXW7-DS-SILY group. d) SIS/DS-SILY/EPCs group compared to SIS/DS-SILY group showed no significant difference. e) SIS/EPCs group compared to SIS group showed no significant difference. Data are expressed as mean ± SEM. SIS group, SIS/LXW7-DS-SILY group, and SIS/EPCs group: n = 8; SIS/DS-SILY group: n = 7; SIS/DS-SILY/EPCs group: n = 11; SIS/LXW7-DS-SILY/EPCs group: n = 12. C. Bioluminescence image of wounds transplanted with different modified scaffolds loaded with ZDF-EPCs. D. Quantification of the bioluminescence signals intensity (Most of the SIS scaffolds spontaneously fall off the wounds by day 11). Data are expressed as mean ± SEM. n = 5 per group. **p < 0.01, *p < 0.05.