Fig. 5.

Transplantation of scar model into adult immunodeficient mice displays characteristics of early stage of scar and confirmed the effect of screened drugs. (A) Schematic illustration of the whole process of animal test. (B) The macroscophic images of scar formation in different groups. (C) HE (Scale bar = 200 μm) and Masson images (Scale bar = 200 μm) of scar tissue in different groups. (D) The expression of myofibroblasts markers in different groups (α-SMA, Col I: red, DAPI: blue, scale bar = 100 μm). 3A5G: 3A5G+SFb+scar ECM, 3A–C: 3ASS+ Cobimetinib, 3A–T: 3ASS+ Triamcinolone acetonide. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)