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. 2021 Nov 16;15:774569. doi: 10.3389/fncel.2021.774569

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Copyright © 2021 Li, Zhang, Jia, Yang, Zhang, Zhang, Li, Jin, Wang, Tao, Chen, Liang and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Electroacupuncture intervention could improve the learning and memory abilities of APP/PS1 mice tested by Morris water maze. (A) The escape latency of five groups in Morris water maze after EA intervention; (B) The escape platform crossing times of five groups in Morris water maze after EA intervention; (C) The 3rd quadrant time percentage of five groups in Morris water maze after EA intervention; (D) Representative images of Morris water maze in different groups. *P < 0.05 vs. the WT group; ^#P < 0.05 vs. the AD group; ^∧P < 0.05 vs. the AD + AMP-activated protein kinase (AMPK)^(+/–) group; ^&P < 0.05 vs. the AD + EA group.