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. 2021 Nov 18;11:768993. doi: 10.3389/fcimb.2021.768993

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Copyright © 2021 Zhao, Han, Zheng, Rao, Li, Chen, Yu, Xu, Chen, Gao and Jiang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immune cross-reactivity of convalescent patient serums with SARS collected from 15 years post-infection against the SARS-CoV-2 spike protein. (A) Heatmap of antibody titres. (B) Histogram of antibody titres expressed in terms of mean and 95% confidence interval (CI). (C) Histogram of OD450 in the ACE2 competition assay in terms of mean and 95% CI. (D) Heatmap of OD450 in the ACE2 competition assay. ****P < 0.0001. ns, no significant difference.