Table 4.

Multivariate models of outcome

		HR (95% CI)	p-value
Non-nodal locoregional control
	Microsatellites	3.4 (1.4–8.2)	0.009
	LVI	2.7 (1.1–6.4)	0.023
Nodal disease control
	LVI	3.84 (1.90–7.76)	<0.005
	≥2 nodes	2.14 (1.07–4.26)	0.03
	>1 mm node	2.21 (1.00–4.92)	0.04
Distant disease control
	LVI	2.24 (1.04–4.82)	0.039
	≥2 nodes	2.51 (1.15–5.48)	0.023
	>1 mm node	2.51 (1.00–6.60)	0.048
Disease-free survival
	LVI	2.36 (1.32–4.23)	0.0037
	>1 mm node	2.29 (1.23–4.22)	0.0057
	Microsatellites	2.73 (1.48–5.02)	0.0023
	Age ≥65	1.87 (1.06–3.30)	0.026

Abbreviations: CI, confidence interval; HR, hazard ratio; LVI, lymphovascular invasion.