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. 2021 Sep 15;10:443–459. doi: 10.1016/j.bioactmat.2021.09.011

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 6 — TE promotes IPFP-MSCs survival and adhesion in SD rat joint cavity. (A) A flow diagram showing the labeled IPFP-MSCs and time of intra-articular injection (only one injection). (B) Sample diagram of rat knee joint (femoral condyle, tibia platform, synovium, and meniscus). (C) Fluorescence labeling of IPFP-MSCs attached to tissues (femoral condyle, tibia platform, synovium, and meniscus) in rat knee joint. (D) Quantitative analysis of IPFP-MSCs adhesion on rat femoral condyle or tibia platform or synovium or meniscus. (n = 6, *P < 0.05, ***P < 0.001). (E) Representative fluorescent in vivo image of OA rat knee joints over 14 days after intra-articular injection of DiR-IPFP-MSCs. Red, Yellow, green or blue arrows indicate femoral condyle, tibia platform, synovium or meniscus respectively. Rainbow color scale (Min: 1e5; Max: 1e6). (F) Quantitative analysis of area based on fluorescence intensity profiles (fluorescent in vivo imaging). (n = 6, *P < 0.05, **P < 0.01, ***P < 0.001).