Table 1.

Quality assessment of included pre-clinical studies using SYRCLE's tool.

Study	Selection bias		Performance bias			Detection bias		Attrition bias	Reporting bias	Other
	Sequence generation	Baseline characteristics	Allocation concealment	Random housing	Blinding	Random outcome assessment	Blinding	Incomplete outcome data	Selective outcome reporting	Other sources of bias
Ay et al. (38)	Yes	Yes	Yes	Unclear	No	Yes	Yes	Yes	Yes	Yes
Ay et al. (39)	Yes	Yes	Yes	Unclear	No	Yes	Yes	Yes	Yes	Yes
Ay and AY (40)	Unclear	Yes	Unclear	Unclear	No	Yes	Yes	Yes	Yes	Yes
Ayajiki et al. (41)	Unclear	Yes	Unclear	Unclear	Yes	Yes	Unclear	Yes	Unclear	Yes
Bar-Shir et al. (42)	Unclear	Yes	Unclear	Unclear	Unclear	Yes	Yes	Yes	Yes	Yes
Borsody et al. (43)	Yes	Yes	Yes	Unclear	Yes	Yes	No	Yes	Unclear	Yes
Borsody et al. (44)	Yes	Yes	Yes	Unclear	Yes	Yes	No	Yes	Unclear	Yes
Chi et al. (45)	Yes	Yes	Yes	Unclear	Yes	Yes	Yes	Yes	Yes	Yes
D'Alecy and Rose (46)	Unclear	Yes	Unclear	Unclear	No	Unclear	No	Yes	Unclear	Yes
Edvinsson et al. (47)	Unclear	Yes	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	Yes
Goadsby et al. (48)	No	Unclear	No	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	Yes
Goadsby et al. (49)	Unclear	Yes	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	Yes
Goadsby et al. (50)	Unclear	Yes	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	Yes
Gulturk et al. (51)	Unclear	Yes	Unclear	Unclear	Yes	Yes	Yes	Yes	Yes	Yes
Gürelik et al. (52)	Unclear	Yes	Unclear	Unclear	Yes	Yes	Yes	Yes	Yes	Yes
Henninger (53)	Unclear	Yes	Unclear	Unclear	Yes	Unclear	Yes	Yes	Yes	Yes
Kuo (54)	Unclear	Yes	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	Yes
Levi et al. (55)	Yes	Yes	Yes	Unclear	No	Yes	Unclear	Unclear	Unclear	Yes
Sanchez et al. (56)	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes
Seylaz et al. (57)	No	Yes	No	Unclear	No	Unclear	Unclear	Yes	Unclear	Yes
Suzuki et al. (58)	Unclear	Yes	Unclear	Unclear	Unclear	Yes	Yes	Yes	Unclear	Yes
Talman (59)	Unclear	Yes	Unclear	Unclear	Yes	Unclear	Unclear	Yes	Yes	Yes