Fig. 3.

(A) Median RER across all treatments was significantly lower for females, and (B) median RER was significantly lower following e-cigarette inhalation only for females. (C) Variation in median RER as a function of treatment in females during morning and afternoon hours, and in PM females (D). (E) Variation in median RER in males during morning and afternoon hours and (F) in AM males as a function of relative age. Mouse age categories were determined by classification analysis of independent variables on treatment (TX). Treatment groups are defined as control (TX = 1) and e-cigarette exposure (TX = 2).