Table 4.

Associations of circulating biomarkers with the primary outcome in the RA Porto cohort.

	LVMi model			LVH model			LAVi model			LAVi > 34 model			E/e′ model			E/e′> 14 model
	HR	p-value	FDR	HR	p-value	FDR	HR	p-value	FDR	HR	p-value	FDR	HR	p-value	FDR	HR	p-value	FDR
TRAILR2	1.59	0.004	0.21	1.65	<0.001	0.033	1.62	<0.001	0.046	1.65	<0.001	0.025	1.63	0.002	0.077	1.61	0.002	0.089
CTSL1	2.99	<0.001	0.007	3.52	<0.001	<0.001	3.40	<0.001	<0.001	3.73	<0.001	<0.001	3.20	<0.001	0.002	3.18	<0.001	0.001

Multivariable model included age, sex, body mass index, diabetes, systolic blood pressure, estimated glomerular filtration rate and rheumatoid arthritis duration plus echocardiographic parameters.

LVMi, left ventricular mass index; LVH, left ventricular hypertrophy; LAVi, left atrial volume index; TRAILR2, TNF-related apoptosis-inducing ligand receptor 2; CTSL1, Cathepsin L1.