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. 2021 Nov 18;12:754125. doi: 10.3389/fphar.2021.754125

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Copyright © 2021 Bi, Yue, Bai, Feng, Xu, Fu, Zhang and Tang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PCA score plots of serum metabolic profile in positive (A) and negative (B) ESI modes. OPLS-DA score plots of serum metabolic profile in positive (C) and negative (D) ESI modes. S-plots of serum metabolic profile in positive (E) and negative (F) ESI modes. VIP-plots of serum metabolic profile in positive (G) and negative (H) ESI modes.