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Forest plot of serum C-reactive protein. CRP was measured in AECOPD cases with bacteria positive and bacteria negative microbiological cultures. CRP was measured in (mg/l) in each study. CRP is significantly elevated in bacterial cases than non-bacterial cases. WMD = 16.06, 95% CI: 2.83–29.32, p = 0.017. AECOPD, acute exacerbation of chronic obstructive pulmonary disease; CRP, C-reactive protein; SD, standard deviation; WMD, weighted mean difference; CI, confidence interval.
