FIGURE 7.

Sonodynamic therapy (SDT)-based cancer theranostics. (A) Schematic illustration of the synthesis procedure of three metal 4-methylphenylporphyrin (TTP) complexes (MnTTP, ZnTTP, and TiOTTP) and the corresponding nanocomplexes of MTTP–HSA. (B) The in vivo T₁-weighted MR images of MCF-7 tumor-bearing nude mice after the i.v. injection of MnTTP–HSA. (C) The in vivo PA images of MCF-7 solid tumors after i.v. injection of MnTTP–HSA. (D) The in vivo SDT protocol of MCF-7 tumor-bearing mouse model with bilateral tumors. The US probe was placed on the right tumor, and the US irradiation was conducted twice at 3 and 24 h, respectively, from the right side to the left side (1.0 MHz, 2 W/ cm², 50% duty cycle, 5 min). (E, F) The tumor growth curves of the left and right tumors, respectively, with various treatments (**p < 0.01). Reproduced with permission from Ma et al. (2019). Copyright 2018, WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim.