TABLE 1.

Summary of representative applications of serum albumin-based nanovehicles for cancer theranostics.

Therapy	Formulation	Nanovehicle type	Therapeutic agent	Imaging modality	Administration route	Applications	Ref.
Gas therapy	IPH-NO	Albumin nanoparticles	NO, PTX, IR780	Fluorescence imaging	Intravenous administration	Breast cancer treatment (4T1 cells)	Xu et al. (2019)
CDT	FeS@BSA	Albumin nanoparticles	Fe2+, H2S	T2-weighted MRI	Intravenous administration	Hepatoma carcinoma treatment (Huh7 cells)	Xie et al. (2020)
PTT	HSA-ICG	Albumin nanoparticles	ICG	NIR fluorescence imaging, PA imaging	Intravenous administration	Breast cancer treatment (4T1 cells)	Sheng et al. (2014)
PDT	HSA-Ce6(Mn)-PTX–RGD	Surface-functionalized albumin nanoparticles	Ce6, PTX	T1-weighted MRI, fluorescence imaging	Intravenous administration	Human glioblastoma treatment (U87MG cells)	Chen et al. (2015)
SDT	MTTP–HSA	Albumin nanocomplexes	metal 4-methylphenylporphyrin (TTP) complexes	T1-weighted MRI, PA imaging	Intravenous administration	Breast cancer treatment (MCF-7 cells)	Ma et al. (2019)
Chemotherapy	DOX/GA-rHSA	Albumin nanoparticles	DOX	Fluorescence Imaging	Intravenous administration	Liver cancer treatment (H22 liver tumors, HepG 2 cells)	Qi et al. (2015)
Immunotherapy	Al-BSA-Ce6	Albumin nanoparticles	Ce6, aluminum adjuvant	Fluorescence imaging	Intravenous administration	Melanoma treatment (B16F10 cells)	Zhu et al. (2020)
Radiotherapy	125I-HSA/131I-HSA	Albumin nanoparticles	125I/131I	SPECT/CT imaging	Intravenous administration	Colon cancer treatment (CT26 cells)	Yi et al. (2020)