Fig. 4.

dECM for skin tissue engineering. (Ⅰ) Histological assessment of human dermis before and after decellularization. Reproduced from Ref. [204]. (Ⅱ) H&E stained cross-section of the vascularized skin equivalent (vSE). (a) Overview of the vSE. (b) Magnification of the area indicated in (a). (c) Detailed view of the epidermal layer. (d) Detailed image of a vascular structure that has been reseeded with human dermal microvascular endothelial cells (hDMEC). (e) Image of the vasculature in efferent vessels. Reproduced from Ref. [221].