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. 2021 Nov 18;12:781127. doi: 10.3389/fmicb.2021.781127

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Copyright © 2021 Marí-Almirall, Ferrando, Fernández, Cosgaya, Viñes, Rubio, Cuscó, Muñoz, Pellice, Vergara, Campo, Rodríguez-Serna, Santana, Del Río, Francino, Ciruela, Ballester, Marco, Martínez, Soriano, Pitart, Vila, Roca and MERCyCAT Study Group.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Schematic representation of the 106,412 bp IncFIIk plasmid from the ST15 K. pneumoniae strain MC-2-1 (pMC-2-1) carrying bla_KPC–2 within a NTE_KPC-pMC-2-1 genetic structure and sequence alignment with similar IncFIIk plasmid backbones from strains MC-2-207, MC-2-315, MC-2-316, MC-2-387, and MC-2-240 (only the aligned region is shown). Arrows are proportional to the lengths of the genes and oriented in the direction of transcription. Red arrows represent resistance genes, orange arrows represent full-length transposon-related genes and ISs, dark blue arrows represent partial or truncated transposon-related genes and ISs, green arrows indicate genes involved in plasmid conjugation and light blue arrows shown genes related to plasmid replication/maintenance. Blue-gray arrows show putative or hypothetical genes and plum arrows show genes involved in other functions. The inner circle shows the GC content. The fully annotated sequence of plasmid pMC-2-1 is shown in Supplementary Figure 3. (B) Schematic representation of the larger IncFIIk plasmids carrying bla_KPC–2 recovered from strains MC-2-230, MC-2-304, and MC-2-363. The location of the genetic structure NTE_KPC-pMC-2-1 harboring bla_KPC–2 is shown as well as the region matching the pMC-2-1 sequence. The inner circle shows the GC content.