Table 2.
Correlations between age and main immune parameters of the postvaccinal response at 3 months in COVID-19-naive young and older participants.
| Correlation | Spearman’s rank (r) | p-value | 95% CI | Sample size |
|---|---|---|---|---|
| Age with | ||||
| Anti-S1 IgG levels | −0.36 | <0.0001 | −0.48; −0.22 | 181 |
| NT50 LV-NT | −0.35 | <0.0001 | −0.48; −0.19 | 146 |
| NT50 PV-NT | −0.56 | <0.0001 | −0.66; −0.44 | 160 |
| S1-reactive T cells (ELISpot) | −0.25 | 0.0008 | −0.38; −0.10 | 179 |
| Anti-S1 IgG antibodies with | ||||
| NT50 LV-NT | 0.79 | <0.0001 | 0.72; 0.85 | 181 |
| NT50 PV-NT | 0.68 | <0.0001 | 0.58; 0.75 | 146 |
| S1-reactive T cells (ELISpot) | 0.45 | <0.0001 | 0.32; 0.56 | 160 |
| NT50 LV-NT with | ||||
| NT50 PV-NT | 0.65 | <0.0001 | 0.53; 0.74 | 127 |
| S1-reactive T cells (ELISpot) | 0.44 | <0.0001 | 0.29; 0.56 | 145 |
| NT50 PV-NT with | ||||
| S1-reactive T cells (ELISpot) | 0.39 | <0.0001 | 0.25; 0.52 | 158 |
All correlations are presented in Figure 3E (with Spearman’s rank correlation (r) coefficients). NT50 LV-NT assay, 50% serum neutralization titer in live virus neutralization assay; NT50 PV-NT assay, 50% serum neutralization titer in pseudovirus neutralization assay; CI, confidence interval.