Table 2.
Association between osteoarthritis and the incidence of Parkinson’s disease in the overall population and in sex and age subgroups.
| Population | Incidence of Parkinson’s disease in patients with osteoarthritisa | Incidence of Parkinson’s disease in patients without osteoarthritisa | Unadjusted hazard ratio (95% confidence interval) | P-value | Adjusted hazard ratio (95% confidence interval)b | P-value |
|---|---|---|---|---|---|---|
| Overall | 124.1 | 67.1 | 1.85 (1.66–2.06) | <0.001 | 1.82 (1.63–2.02) | <0.001 |
| By sex | ||||||
| Female | 101.1 | 52.6 | 1.92 (1.65–2.24) | <0.001 | 1.88 (1.61–2.19) | <0.001 |
| Male | 161.8 | 90.8 | 1.78 (1.53–2.07) | <0.001 | 1.75 (1.51–2.04) | <0.001 |
| By age (in years) | ||||||
| Age ≤ 50 | 14.7 | 4.2 | 3.48 (1.15–10.58) | 0.028 | 3.22 (1.06–9.38) | 0.040 |
| Age 51–60 | 39.1 | 17.9 | 2.18 (1.47–3.24) | <0.001 | 2.12 (1.43–3.14) | <0.001 |
| Age 61–70 | 116.3 | 54.1 | 2.15 (1.72–2.68) | <0.001 | 2.14 (1.72–2.67) | <0.001 |
| Age 71–80 | 243.7 | 136.8 | 1.78 (1.52–2.09) | <0.001 | 1.79 (1.53–2.09) | <0.001 |
| Age > 80 | 218.3 | 139.8 | 1.56 (1.24–1.96) | <0.001 | 1.59 (1.27–1.99) | <0.001 |
a
Number of patients diagnosed with Parkinson’s disease per 100,000 people.
b
Adjusted Cox regression models included hypertension, diabetes mellitus, thyroid diseases, dyslipidemia, coronary heart disease, gout, chronic obstructive pulmonary disease, stroke including transient ischemic attack, and intracranial injury.