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. 2021 Nov 18;12:761791. doi: 10.3389/fgene.2021.761791

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Copyright © 2021 Bolognini and Magi .

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Precision (y axis), recall (x axis) and F-score (dashed lines) of the SV callers Sniffles (square symbol), SVIM (cross symbol), cuteSV (circle symbol) and pbsv (triangle symbol) after minimap2 (top panels), NGMLR (mid panels) and lra (bottom panels) alignments. Results for both SV calling (left panels) and genotyping (right panels) are reported. The plot shows the influence of average genome coverage after down-sampling NA24385 alignments to different fractions (5X, 10X, 15X, 20X, 25X, 35X–hue palette) of the original coverage (total) on SV callers' performances.