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. 2021 Nov 18;11:781471. doi: 10.3389/fonc.2021.781471

Figure 3.

Figure 3

Hsa_circ_0001367 act as a sponge of miR-545-3p. (A) The binding sites between hsa_circ_0001367 and miR-545-3p. (B) Dual-luciferase reporter assay showed that miR-545-3p could more greatly decrease the luciferase activity of circ_0001367-WT than circ_0001367-MUT. (C, D) RIP assay was performed to verify the relationship between circ_0001367 and miR-545-3p. (E) qRT-PCR was used to detect the expression of miR-545-3p in clinical samples. (F) qRT-PCR was used to detect the expression of miR-545-3p in NHAs and glioma cell lines. (G) The expression of miR-545-3p in T98G and LN229 cells transfected with circ_0001367 plasmid was detected by qRT-PCR. **P < 0.01.