Figure 1.

UAMC-2526 inhibits Panc02 cell proliferation. (A) Panc02 cells were treated in vitro with different concentrations of UAMC-2526 in the presence or absence of gemcitabine (10 µM). Cell proliferation was measured at different time points with neutral red. Data were analyzed using one sample t-test. Six independent experiments were performed. After normalization, the resulting fold change was log transformed (log2-base) to obtain an approximately normal distribution. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001 versus DMSO group. (B) Panc02 cells were treated in vitro with different concentrations of UAMC-2526 in the presence or absence of gemcitabine (10 µM). Cell death was measured at different time points by propidium iodide (PI) labeling. Five independent experiments were performed. Two-way ANOVA followed by Dunnett’s post hoc test. **p ≤ 0.01, ***p ≤ 0.001 versus DMSO group.