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. 2021 Nov 18;11:750259. doi: 10.3389/fonc.2021.750259

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Copyright © 2021 Takhsha, Vangestel, Tanc, De Bruycker, Berg, Pintelon, Stroobants, De Meyer, Van Der Veken and Martinet

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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UAMC-2526 has no impact on autophagy in Panc02 tumors. (A) C57/BL6 mice with Panc02 tumors were treated with vehicle (control), UAMC-2526 (UAMC), gemcitabine (GEM) or a combination of UAMC-2526 and gemcitabine. After treatment, western blots were performed on Panc02 tumor lysates to detect LC3-II and p62. β-actin served as a loading control. Representative images are shown. (B) Quantification of LC3-II and p62 relative to β-actin. Data were analyzed using one-sample t-test. After normalization, the resulting fold change was log transformed (log2-base) to obtain an approximately normal distribution. Number of animals in each group was between 8-10. No significance was demonstrated.