Table 2. Association of Psoriasis With Venous Thromboembolism According to Subgroups.
Subgroups | Venous thromboembolism | Subgroup differences | ||||
---|---|---|---|---|---|---|
No. of studies | Pooled HR (95% CI) | P value | I2 (%) | P value | I2 (%) | |
Arthritis status | ||||||
Psoriasis alone | 2 | 0.97 (0.78-1.21) | .79 | 89 | .11 | 61.2 |
Psoriatic arthritis | 3 | 1.24 (1.01-1.53)a | .04 | 82 | ||
Psoriasis severity | ||||||
Mild psoriasis | 1 | 1.07 (1.03-1.12)a | .002 | NA | .45 | 0 |
Severe psoriasis | 1 | 1.13 (0.99-1.30) | .08 | NA | ||
Sex | ||||||
Men | 2 | 1.40 (0.90-2.19) | .13 | 93 | .29 | 9.2 |
Women | 3 | 1.89 (1.36-2.61)a | <.001 | 84 | ||
Geographic location | ||||||
US | 2 | 1.07 (0.67-1.70) | .78 | 86 | .04 | 68.3 |
Asia | 1 | 2.02 (1.42-2.88)a | <.001 | NA | ||
Europe | 4 | 1.28 (1.06-1.53)a | .01 | 95 |
Abbreviations: HR, hazard ratio; NA, not applicable.
P < .05.