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. 2021 Nov 18;13:748929. doi: 10.3389/fnsyn.2021.748929

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Copyright © 2021 Kearns, Jayasi, Liu, Wang, Shi, Chung, La, Tang and Bae.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Repeated morphine treatment decreases inhibitory synaptic strength in sNK1Rn. (A) Representative traces of evoked inhibitory postsynaptic current (eIPSC) from sNK1Rn. Stimulus-response curve of eIPSC from panel (B) sNK1Rn (Vehicle: N = 4, n = 9; Morphine: N = 4, n = 19) and (C) sGABAn (Vehicle: N = 7, n = 48; Morphine: N = 6, n = 26). ns: not significant, ^∗p < 0.05 vs. vehicle by Sidak’s multiple comparison test following multilevel analysis. (D) eIPSC (at 140 μA) of sNK1Rn and sGABAn from panels (B,C), respectively. Effect size: –3.34, p = 0.0037 for sNK1Rn: Vehicle vs. Morphine. Effect size: 0.37, p = 0.5718 for sGABAn: Vehicle vs. Morphine. Effect size: –6.73, p = 0.002 between Veh:sNK1Rn and Veh:sGABAn. Effect size: –0.27, p = 0.734 between Mor:sNK1Rn and Mor:sGABAn. ^∗∗p < 0.01; Welch’s t test.