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. 2021 Nov 18;13:748929. doi: 10.3389/fnsyn.2021.748929

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Copyright © 2021 Kearns, Jayasi, Liu, Wang, Shi, Chung, La, Tang and Bae.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Rheobase of sNK1Rn and sGABAn. Repeated morphine treatment decreased sNK1Rn rheobase (Effect size: –2.48, p = 0.022; Vehicle: N = 4, n = 21, Morphine: N = 4, n = 17) but had no significant effect on sGABAn rheobase (Effect size: 0.15, p = 0.812; Vehicle: N = 4, n = 45, Morphine: N = 5, n = 28) ^∗p < 0.05 vs. vehicle by Welch’s t test. ns: not significant. In vehicle groups, rheobase of sGABAn was significantly smaller in comparison to sNK1Rn (Effect size: –2.55, p = 0.026). ^∗p < 0.05 vs. vehicle of sNK1Rn by ordinary one-way ANOVA with Tukey’s multiple comparisons test.