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. Author manuscript; available in PMC: 2022 Dec 1.
Published in final edited form as: Br J Pharmacol. 2021 Sep 26;178(24):4842–4858. doi: 10.1111/bph.15662

FIGURE 3.

FIGURE 3

The concentration-dependence of diazepam action on currents mediated by wildtype GABAA receptors and activated by EC5 GABA in the presence of 200-μM flumazenil. (a) Representative traces showing the impact of diazepam on GABA-activated currents at the indicated concentrations. Each trace was derived using a different oocyte. (b) Diazepam concentration–response relationship for GABA-activated currents in the presence of 200-μM flumazenil. Each point represents the mean ± SD of normalized currents from five different oocytes. Closed circles represent the potentiated current amplitude and open circles represent the inhibited current amplitude. Each point was evaluated using a one-way t-test against a hypothetical mean of 100% and an adjusted P value was derived using a Benjamini–Hochberg correction for multiple comparisons. *P < 0.05