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. Author manuscript; available in PMC: 2022 Dec 1.
Published in final edited form as: Br J Pharmacol. 2021 Sep 26;178(24):4842–4858. doi: 10.1111/bph.15662

FIGURE 7.

FIGURE 7

The concentration-dependence of midazolam and flurazepam action on currents mediated by wildtype GABAA receptors and activated by EC5 GABA in the presence of 200-μM flumazenil. Representative traces showing the impact of (a) midazolam and (b) flurazepam on GABA-activated currents at the indicated concentrations. Each trace was derived using a different oocyte. (c) Benzodiazepine concentration–response relationships for GABA-activated currents in the presence of 200-μM flumazenil. Each point represents the mean ± SD of normalized currents from five different oocytes. Midazolam is represented by diamonds and flurazepam by squares. For midazolam, in which both potentiated and inhibited currents were commonly present, closed diamonds represent the potentiated currents and open diamonds represent the inhibited current. Each data point was evaluated using a one-way Student's t-test against a hypothetical mean of 100% and an adjusted P value was derived using a Benjamini–Hochberg correction for multiple comparisons. +P < 0.05, (flurazepam)