TABLE 1.
Genes affected by PBM during tendon maturation and healing (descriptions from UniProt38)
| Sex | Gene | P value | PBM/Ctrl | Function |
|---|---|---|---|---|
| Maturation: Low power | ||||
| M | Slc25a23 | .034 | 1.16 | Mediates the transport of Mg-ATP in exchange for phosphate, catalyzing uptake, or efflux of adenine across the inner membrane. Regulates calcium uptake via interaction with MCU and MICU1. |
| M | Slc25a24 | .018 | 1.29 | Protects cells against oxidative stress-induced cell death by promoting the formation of calcium-phosphate precipitates in the mitochondrial matrix, and thereby buffering calcium levels in the matrix. |
| F | Bbc3 | .036 | 0.67 | Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis. Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53. Regulates ER stress-induced neuronal apoptosis. |
| Maturation: High power | ||||
| F | Slc25a24 | .039 | 1.339 | Described above. |
| M | Ucp2 | .036 | 0.653 | Mitochondrial transporter protein that creates proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. |
| M | Slc25a23 | .014 | 0.578 | Described above. |
| M | Slc25a13 | .021 | 0.489 | Catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the inner membrane. May have a function in the urea cycle. |
| Healing | ||||
| F | Bcl2 | .034 | 1.228 | Suppresses apoptosis in a variety of cell systems by controlling the mitochondrial membrane permeability. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor. |
| F | Slc25a19 | .025 | 1.351 | Mitochondrial transporter mediating uptake of thiamine pyrophosphate into mitochondria. |
| F | Slc25a37 | .036 | 1.14 | Mitochondrial iron transporter that plays an essential role in heme biosynthesis. The iron delivered into the mitochondria may be delivered to ferrochelatase to catalyze Fe2+ incorporation into protoporphyrin IX to make heme. |
| F | Slc25a13 | .028 | 0.78 | Described above. |
Abbreviations: ATP, adenosine triphosphate; Ctrl, control; ER, estrogen receptor; PBM, photobiomodulation.