Table 3.
Batches prepared by high pressure homogenization.
| Batch | Drug mg | HPMC 3cps mg | Poloxamer 407 mg | SLS mg | Particle size (Z- Avg nm) | PDI | Zeta potential (mV) |
|---|---|---|---|---|---|---|---|
| 1 | 100 | 100 | 60 | 12.5 | 223.3 | 0.262 | -21.2 |
| 2 | 100 | 100 | 80 | 20 | 146 | 0.414 | -12.3 |
| 3 | 100 | 100 | 40 | 5 | 248.3 | 0.596 | -7.09 |
| 4 | 100 | 100 | 12.5 | 31.71 | 223.2 | 0.431 | -9.25 |
| 5 | 100 | 100 | 60 | 12.5 | 223.3 | 0.262 | -21.2 |
| 6 | 100 | 100 | 88.28 | 12.5 | 423.4 | 0.630 | -0.835 |
| 7 | 100 | 100 | 60 | 12.5 | 223.3 | 0.262 | -21.2 |
| 8 | 100 | 100 | 60 | 12.5 | 223.3 | 0.262 | -21.2 |
| 9 | 100 | 100 | 60 | 23.10 | 191.4 | 0.554 | -11.8 |
| 10 | 100 | 100 | 60 | 1.89 | 364.3 | 0.716 | -10.6 |
| 11 | 100 | 100 | 40 | 20 | 119.5 | 0.59 | -10.5 |
| 12 | 100 | 100 | 60 | 12.5 | 223.3 | 0.262 | -21.2 |
| 13 | 100 | 100 | 80 | 5 | 149.2 | 0.615 | -7.78 |