Fig. 8.

iNKT cells efficiently kill patient‐derived colon cancer cells. (A) Cytotoxicity at 8 : 1 E : T ratio. (B) Frequencies of Fas ligand (left) and TRAIL (right)‐positive iNKT cells after incubation with CRC cells (C) Representative dot plots showing granzyme B expression. (D) Frequencies of granzyme B‐positive cells (left) and granzyme B levels (right) after CRC cell encounter. (E) Representative dot plots showing perforin expression. (F) Frequencies of PRF‐positive cells (left) and perforin levels (right) after CRC cell encounter. Kruskal–Wallis test was used to assess statistical significance, and Dunn’s test was used for multiple comparisons. ns. nonsignificant, P‐value < 0.05 (*), 0.01 (**), 0.001 (***), 0.0001 (****). Data are means ± SD of 4 pooled patients.