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. 2021 Jun 1;15(12):3447–3467. doi: 10.1002/1878-0261.12998

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© 2021 The Authors. Molecular Oncology published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Fig. 1 — Serum Cyr61 is a diagnostic marker for CRC. (A) qRT‐PCR analysis of Cyr61 mRNA levels in ADSCs‐NC (n = 9) and ADSCs‐CRC (n = 11). (B) ELISA of Cyr61 levels in the medium of ADSCs‐NC (n = 9) and ADSCs‐CRC (n = 11). (C) ELISA of serum Cyr61 levels in healthy donors (n = 90) and CRC patients (n = 364). (D) ELISA of serum Cyr61 levels in different CRC tumor stages. (E) ROC curves for diagnosis of CRC via serum Cyr61, CA125, CEA, or CA199 levels. (F) Decision curve for diagnosis of CRC via serum Cyr61, CA125, CEA, or CA199 levels. Values are represented as mean ± SD. ***P < 0.001, by two‐tailed Student's t‐test (A–C) and one‐way ANOVA (D).