TABLE 1.

Studies on non-auditory noise effects on cardiovascular and endothelial dysfunction, inflammation or oxidative stress in animals ^a . Only articles that are not discussed in detail in the main article text are listed here.

Study	Animals and model	Noise scenario	Major outcome of noise exposure	Ref
Peterson 1981	Rhesus Monkey	85 dB, 97 dB peak, unknown type, 9 months	Blood pressure elevation ∼30 mmHg	Peterson et al. (1981)
Borg 1981	Rat	80 dB, 100 dB, unknown type, 10 h, lifelong	Noise-exposed spontaneously hypertensive rats had shorter lifespan and higher incidence of cardiovascular disease, but no differences were found in normotensive rats	Borg and Jarplid (1981)
Peterson 1984	Macaque Monkey	86.6 dB, construction noise, 4 h/8 h, 97 days	Mean blood pressure elevation remained elevated after noise cessation, but heart rate returned to normal relatively quickly	Peterson et al. (1984b)
Kirby 1984	Macaque Monkey	95 dB, broadband noise, 30 m	Offspring of hypertensive monkeys were more sensitive to blood pressure increases from loud noise	Kirby et al. (1984)
Dengerink 1985	Guinea Pigs	120 dB, white noise, 30 m	Effects in cochlear vessel lumen and RBC behavior appear to normalize after 2 days of “noise washout”	Dengerink et al. (1985)
Paparelli 1992	Rat	100 dB, white noise, 12 h	Increased density of noradrenergic cardiac fibers in young animals. In aged animals, increased aortic maximal response to the α-agonist on the aortic musculature and reduced responsiveness to the β-agonist in cardiac fibers	Paparelli et al. (1992)
Morvai 1994	Rat	95 dBA, industrial noise, 6 h, 3 weeks	Noise and alcohol modify the α-adrenergic effect of noradrenaline	Morvai et al. (1994)
Herrmann 1994	Rat	65 dBA, unknown type, 52 weeks	Increased microvessel area, cardiac fibrosis, and ischemic myocardial lesions in SHR exposed to noise	Herrmann et al. (1994)
Breschi 1995	Rat	100 dB, white noise, 1 h/6 h	Diazepam and clonazepam pre-treatment reversed the effects of noise on CBR binding and protected cardiac tissue and aortic responses from the effects of 6 h noise stress	Breschi et al. (1995)
Salvetti 2000	Rat	100 dBA, white noise, 6/12 h	Significant decrease in the binding sites availability of peripheral benzodiazepine receptors following noise	Salvetti et al. (2000)
Singewald 2000	Rat	95 dB, unknown type, 3 m	Noise stress resulted in exaggerated glutaminergic responses in the amygdala of SHR versus Wistar-Kyoto	Singewald et al. (2000)
Bauer 2001	Sheep	161 dB, airborne impulse noise, 20 impulses	Fetal heart rate was affected in both REM and NREM sleep, power of delta, theta, and alpha band power was reduced and cortical activity was detected	Bauer et al. (2001)
Gesi 2002	Mouse	100 dBA, white noise, 6 h	Cardiomyocytes from the right atria and left ventricles display disarranged cristae and matrix dilution in mitochondria	Gesi et al. (2002)
Lenzi 2003	Rat	100 dBA, white noise, 12 h	Increased catecholamine content in myocardium, DNA damage in cardiomyocytes, mitochondrial membrane swelling in right atrium	Lenzi et al. (2003)
Frenzilli 2004	Rat	100 dBA, white noise, 12 h	DNA damage in the adrenal gland, possible redox involvement	Frenzilli et al. (2004)
Baldwin 2007	Rat	90 dB, unknown type, 15 m, 3/5 weeks	Noise increased leakiness of mesenteric arteries, mitigated by vitamin c	Baldwin and Bell (2007)
Antunes 2013	Rat	90 dB, low frequency, unknown duration	Significant myocardial fibrosis detected via CAB staining and alterations in connexin 43 and collagen expression in noise-exposed rats	Antunes et al. (2013a); Antunes et al. (2013b); Antunes et al. (2013c)
Arpornchayanon 2013	Guinea Pigs	106 dB, unknown type, 30 m	TNF-α signaling is activated in the cochlea following noise exposure, causing vessel constriction. Improved by etanercept.	Arpornchayanon et al. (2013)
Gannouni 2013	Rat	70 dB, 80 dB, unknown type, 6 h, 90 days	Increased corticosterone levels, affected various parameters of the endocrine glands and cardiac function. Markers of oxidative stress (catalase, superoxide dismutase and lipid peroxidation) were increased	Gannouni et al. (2013)
Gannouni 2014	Rat	70 dBA, unknown type, 6 h/day, 3/5 m	Structural alterations within the adrenal gland consistent with chronic stress. Signs of necrosis and inflammation in myocardium	Gannouni et al. (2014)
Said 2016	Rat	80–100 dB, chronic and intermittent, unknown type, 8 h, 20 days	Increases in plasma levels of corticosterone, adrenaline, noradrenaline, endothelin-1, nitric oxide and malondialdehyde. Decreases in superoxide dismutase	Said and El-Gohary (2016)
Lyamin 2016	Beluga Whale	140–175 dB, unknown type, 2–4 h, 60 events	Heart rate acceleration following noise exposure. Calves were more susceptible to the effects of noise and did not habituate	Lyamin et al. (2016)
Konkle 2017	Rat	87.3 dBA, unknown type, 15 min–1 h, 21 days	Plasma ACTH, adrenal gland weight, IL6, IL1b levels were unchanged following noise exposure. Increases in TNFα and CRP were seen.	Konkle et al. (2017)
Lousinha 2018	Rat	120 dB, high intensity infrasound, 28 days	Exposed mice had prominent perivascular tissue with notable fibrosis that was mitigated by dexamethasone treatment.	Lousinha et al. (2018)
Yang 2020	Mouse	105 dB SPL, unknown type, 1/4 h	DNA damage response genes appear to fail to respond to noise-induced DNA damage in cochlea, heart, liver, and cortex	Yang and Guthrie (2020)
Lousinha 2020	Rat	120 dB, high intensity infrasound, 12 weeks	Atrial interstitial fibrosis was increased and connexin 43 weas decreased following noise exposure	Lousinha et al. (2020)
Kvandova 2020	Mouse	72 dBA, intermittent aircraft, 4 days	Oxidative parameters and DNA damage increased following noise exposure with synergetic increases in Ogg-/- mice.	Kvandova et al. (2020)
Gogokhia 2021	Rat	High intensity white noise, 1 h, 10 days	Male rats show higher anxiety-like response following noise	Gogokhia et al. (2021)
Bayo Jimenez 2021	Mouse	72 dBA, intermittent aircraft, 4 days	Induction of NRF2/HO-1 protected against oxidative damage, normalized blood pressure, and vascular endothelial function	Bayo Jimenez et al. (2021)

^aTable was taken from PhD thesis of Katie Frenis.