Table 2.
Detection of taxa significantly associated with MUD by MaAsLin2.
| Taxa | Model 1 (unadjusted) | Model 2 (adjusted for age, BMI, AUDIT score, and FTND score) | ||||
|---|---|---|---|---|---|---|
| Coef.# | p value | q value | Coef.# | p value | q value | |
| p:Actinobacteria | 0.0254 | 0.1014 | 0.6085 | 0.0626 | 0.0060 | 0.1096* |
| p:Firmicutes; c:Bacilli | -0.0135 | 0.0002 | 0.0018** | -0.0134 | 0.0128 | 0.2345* |
| p:Proteobacteria;c:Betaproteobacteria | 0.0386 | 0.0346 | 0.1903* | 0.0207 | 0.4583 | 0.7180 |
| p:Actinobacteria; c:Actinobacteria | 0.0255 | 0.1005 | 0.2762 | 0.0629 | 0.0058 | 0.1592* |
| p:Firmicutes; c:Bacilli; o:Lactobacillales | -0.0138 | 0.0002 | 0.0021** | -0.0139 | 0.0107 | 0.1387* |
| p:Actinobacteria; c:Actinobacteria; o:Coriobacteriales | 0.0215 | 0.0123 | 0.0796* | 0.0557 | 5.94E-07 | 3.86E-05** |
| p:Proteobacteria; c:Betaproteobacteria; o:Burkholderiales | 0.0386 | 0.0345 | 0.1496* | 0.0208 | 0.4569 | 0.6906 |
| p:Firmicutes; c:Bacilli; o:Lactobacillales; f:Streptococcaceae | -0.0098 | 0.0047 | 0.0858* | -0.0110 | 0.0312 | 0.4957 |
| p:Actinobacteria; c:Actinobacteria; o:Coriobacteriales; f:Coriobacteriaceae | 0.0220 | 0.0127 | 0.0858* | 0.0575 | 5.52E-07 | 5.52E-05** |
| p:Firmicutes; c:Clostridia; o:Clostridiales; f:Clostridiaceae1 | -0.0290 | 0.0129 | 0.0858* | -0.0322 | 0.0651 | 0.5099 |
| p:Firmicutes; c:Clostridia; o:Clostridiales; f:Lachnospiraceae; g:Blautia | -0.0338 | 0.0011 | 0.0539* | -0.0237 | 0.1234 | 0.6760 |
| p:Firmicutes; c:Clostridia; o:Clostridiales; f:Ruminococcaceae; g:Faecalibacterium | -0.1369 | 0.0049 | 0.1045* | -0.0874 | 0.2228 | 0.6853 |
| p:Actinobacteria; c:Actinobacteria; o:Coriobacteriales; f:Coriobacteriaceae; g:Collinsella | 0.0275 | 0.0061 | 0.1045* | 0.0664 | 6.11E-07 | 0.0002** |
| p:Firmicutes; c:Clostridia; o:Clostridiales; f:Clostridiaceae1; g:Clostridium sensu stricto | -0.0317 | 0.0127 | 0.1625* | -0.0365 | 0.0579 | 0.5473 |
| p:Bacteroidetes; c:Bacteroidia; o:Bacteroidales; f:Porphyromonadaceae; g:Odoribacter | 0.0223 | 0.0232 | 0.2202* | 0.0474 | 0.0016 | 0.1328* |
| p:Firmicutes; c:Clostridia; o:Clostridiales; f:Lachnospiraceae; g:Dorea | -0.0207 | 0.0295 | 0.2202* | -0.0147 | 0.3240 | 0.7311 |
| p:Firmicutes; c:Bacilli; o:Lactobacillales; f:Streptococcaceae; g:Streptococcus | -0.0084 | 0.0302 | 0.2202* | -0.0083 | 0.1406 | 0.6766 |
#Coefficients from the generalized linear model using MaAsLin2 on pairwise testing between the two groups. *q < 0.25; **q < 0.05; q values were calculated using Benjamin-Hochberg correction (FDR). In Model 2, taxa with significant difference and their q values were bolded. p, phylum; c, class; o, order; f, family; g, genus.