Table 3.
Correlations between altered fecal microbiota, clinical variables and markers of systemic inflammation. .
| Interactions between variables | Correlation coefficient (r) | p value | q value | |
|---|---|---|---|---|
| Fecal Microbiota × Clinical Variables | ||||
| Age of First Use | p:Actinobacteria; c:Actinobacteria# | -0.4853 | 0.0221 | 0.0441 |
| o:Coriobacteriales; f:Coriobacteriaceae# | -0.5638 | 0.0063 | 0.0390 | |
| g:Collinsella | -0.5181 | 0.0135 | 0.0390 | |
| g:Blautia | -0.6656 | 0.0007 | 0.0159 | |
| Total Years of Use | o:Coriobacteriales; f:Coriobacteriaceae# | 0.5666 | 0.0060 | 0.0390 |
| g:Collinsella | 0.5312 | 0.0110 | 0.0390 | |
| g:Blautia | 0.4395 | 0.0407 | 0.0472 | |
| Months of Abstinence | o:Lactobacillales | 0.4233 | 0.0496 | 0.0496 |
| Fecal Microbiota × Systemic Inflammation | ||||
| CRP | g:Megasphaera | 0.5221 | 0.0127 | 0.0390 |
| IL-6 | p:Actinobacteria; c:Actinobacteria# | -0.4501 | 0.0356 | 0.0472 |
| g:Dorea | 0.5244 | 0.0122 | 0.0390 | |
| IL-10 | c:Bacilli | 0.4529 | 0.0343 | 0.0472 |
| o:Lactobacillales | 0.4660 | 0.0288 | 0.0472 | |
| f:Streptococaceae; g:Streptococcus# | 0.5137 | 0.0145 | 0.0390 | |
| IL-2 | g:Blautia | 0.5069 | 0.0161 | 0.0390 |
| Systemic Inflammation × Clinical Variables | ||||
| Age of First Use | IL-2 | -0.4394 | 0.0408 | 0.0472 |
| IL-10 | -0.4252 | 0.0485 | 0.0496 | |
| Frequency of Use | CRP | -0.4438 | 0.0385 | 0.0472 |
| IL-6 | -0.4270 | 0.0475 | 0.0496 | |
| Craving | CRP | -0.5003 | 0.0177 | 0.0390 |
| IL-10 | 0.4408 | 0.0401 | 0.0472 | |
| GAD-7 | IL-10 | -0.4667 | 0.0285 | 0.0472 |
Spearman partial correlation adjusting for age, BMI, AUDIT score, and FTND score (N =26). Q values were calculated using Benjamin-Hochberg correction (FDR); q values < 0.05 were bolded. #The taxa showed the same relative abundance at both taxa levels. c, class; o, order; f, family; g, genus; CRP, C-reactive protein; IL, Interleukin; GAD-7, General Anxiety Disorder Scale-7.