Table 2.
Comparison of comorbid conditions and complications for patients hospitalized with Clostridioides difficile infection with coexisting nonalcoholic fatty liver disease, viral liver disease and alcoholic liver disease
|
Variables
|
CDI with NAFLD
|
CDI with VLD
|
CDI with ALD
|
P
value
|
|
|
n
(weighted)
|
7239
|
11857
|
5938
|
CDI with NAFLD vs CDI with VLD
|
CDI with NAFLD vs CDI with ALD
|
| Number of Elixhauser comorbidities | < 0.0001 | < 0.0001 | |||
| 0 | 0 (0%) | 114 (1%) | - | ||
| 1 | 244 (3.4%) | 574 (4.8%) | 116 (2%) | ||
| 2 | 656 (9.1%) | 1409 (11.9%) | 354 (6%) | ||
| ≥ 3 | 6338 (87.6%) | 9760 (82.3%) | 5463 (92%) | ||
| Obesity | 2012 (27.8%) | 850 (7.2%) | 372 (6.3%) | < 0.0001 | < 0.0001 |
| Diabetes | 2750 (38%) | 3451 (29.1%) | 1170 (19.7%) | < 0.0001 | < 0.0001 |
| Hypertension | 4300 (59.4%) | 6347 (53.5%) | 2980 (50.2%) | 0.00058 | < 0.0001 |
| Dyslipidemia | 2619 (36.2%) | 1868 (15.8%) | 905 (15.2%) | < 0.0001 | < 0.0001 |
| Hepatocellular carcinoma | - | 253 (2.1%) | 45 (0.8%) | < 0.0001 | 0.0217 |
| Cirrhosis related comorbidities1 | |||||
| Cirrhosis | 401 (5.5%) | 2508 (21.2%) | 3407 (57.4%) | < 0.0001 | < 0.0001 |
| Number of cirrhosis complications | 0.0013 | < 0.0001 | |||
| 0 | 137 (34.2%) | 1773 (70.7%) | 2105 (61.8%) | ||
| 1 | 244 (60.8%) | 688 (27.4%) | 1104 (32.4%) | ||
| v ≥ 2 | 20 (5.0%) | 47 (1.9%) | 198 (5.8%) | ||
| Ascites | 0 (0%) | 0 (0%) | 0 (0%) | NA | NA |
| Esophageal varices bleeding | 0 (0%) | - | 20 (0.6%) | NA | NA |
| Hepatic encephalopathy | 110 (27.4%) | 60 (2.4%) | 569 (16.7%) | 0.003338 | < 0.0001 |
| Hepatorenal syndrome | 0 (0%) | 15 (0.6%) | 33 (1.0%) | NA | NA |
| Portal hypertension | 175 (43.6%) | 661 (26.4%) | 843 (24.7%) | < 0.0001 | < 0.0001 |
| Spontaneous bacterial peritonitis | 0 (0%) | 38 (1.5%) | 40 (1.2%) | NA | NA |
1
Value reported as percentage of all cirrhotic patients.
Values reported as weighted number [n (%)].-: Numbers were not displayed due to extremely small numbers were associated with increased risk for identification of persons; CDI: Clostridioides difficile infection; NAFLD: Nonalcoholic fatty liver disease; VLD: Viral liver disease; ALD: Alcoholic liver disease; NA: Not available.